Office location: Upham 205
Phone: (262) 472-5137
Michael J. Woller (1995-Present) Animal Physiologist, Endocrinologist
Ph.D., 1991, Endocrinology and Reproductive Physiology, University of Wisconsin-Madison
Biological Foundations, Biology of the Brain, Animal Physiology, and Endocrinology
Research interests center on measurement of complex neuroendocrine signals from the hypothalamus, observation of how pituitary cells process these complex signals, and measurement of endocrine release from the pituitary gland. Most of this work involves the central mechanisms for reproductive function. The main approach used in the Woller lab centers around the use of a continuous flow perifusion culture system in which we can measure hormone release in real-time from either hypothalamic or pituitary tissues in culture. We have used brain and pituitary tissue isolated from rhesus monkey, rat, marmoset monkey, frog, trout and salmon. This laboratory also uses whole animal models (rats, rhesus monkey, common marmoset) with several sophisticated surgical procedures to isolate various components of the tissues which interact to regulate the hormone production and release involved in neural reproductive function. Other methods employed include immunocytochemistry, cell culture and radioimmunoassay of LH, FSH, mGnRH, chGnRH II and sGnRH.
Publications since 1995:
Dickerson, SM, Cunningham, SL, Patisaul, HB, Woller, MJ, Gore, AC. Endocrine disruption of brain sexual differentiation by developmental PCB exposure. Endocrinology 2011, in press.
Woller, M.J., Tannenbaum, P.L., Schultz-Darken, N.J., Abbott, D.H. Contrasting GnRH release from hypothalamic explants of male marmoset monkeys compared to male rats.American Journal of Physiology-Comparative and Integrative Physiology, 298:70-78, 2010.
Dickerson, SM, Guevara, E, Woller, MJ, Gore, AC. Cell death mechanisms in GT1-7 GnRH cells exposed to polychlorinated biphenyls PCB74, PCB118, and PCB153. Tox App Pharm 237:237-245, 2009.
Maffucci, J, Walker DM, Ikegami A, Woller, MJ, Gore, AC. NMDA Receptor Subunit NR2b: Effects on LH Release and GnRH Gene Expression in Young and Middle-aged Female Rats, with Modulation by Estradiol. Neuroendocrinology 87:129-141, 2008.
Steinberg, RM, Walker, DM, Juenger, TE, Woller, MJ, Gore, AC. Effects of Perinatal Polychlorinated Biphenyls on Adult Female Rat Reproduction: Development, Reproductive Physiology, and Second Generational Effects. Biol Reprod 78:1091-1101, 2008.
Tannenbaum, P.L., Schultz-Darken, N.J., Saltzman, W., Terasawa, E., Woller, M.J., Abbott, D.H. Gonadotrophin-releasing hormone (GnRH) release in marmosets I: In vivo measurement in ovary-intact and ovariectomised females. Journal of Neuroendocrinology, 19:1-12, 2007.
Tannenbaum, P.L., Schultz-Darken, N.J., Woller, M.J., Abbott, D.H. Gonadotrophin-releasing hormone (GnRH) release in marmosets II: Pulsatile release of GnRH and pituitary gonadotrophin in adult females. Journal of Neuroendocrinology, 19:13-22, 2007.
Trewin AL, Woller M, Wimpee BA, Conley LK, Baldridge MG, Hutz RJ.
Short-term hormone release from adult female rat hypothalamic and
pituitary explants is not altered by 2,3,7,8-tetrachlorodibenzo-/p/-dioxin. J Reprod Develop 53:765-775, 2007.
Roberts, JL, Mani, SK, Woller, MJ, Glucksman, MJ, Wu, TJ. LHRH-(1-5), a bioactive peptide regulating reproduction. Trends in Endocrinology and Metabol 18:386-392, 2007.
Al-Kindi, A.Y., Mahmoud, I.Y., Woller, M.J., Plude, J.L. Oviductal morphology in relation to hormonal levels in the snapping turtle, Chelydra serpentina. Tissue Cell, 38:19-33, 2006.
Woller, M.J., Meyer, S., Ada Nguema, A., Waechter-Brulla, D. Dissecting autocrin